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product name
Discovery®Cyano HPLCカラム, 5 μm particle size, L × I.D. 25 cm × 4.6 mm
物質
stainless steel column
認証
suitable for USP L10
製品種目
Discovery®
特徴
endcapped
メーカー／製品名
Discovery®
包装
1 ea of
標識化の程度
4.5% Carbon loading
パラメーター
≤70 °C temp. range
400 bar pressure (5801 psi)
テクニック
HPLC: suitable
LC/MS: suitable
L × 内径
25 cm × 4.6 mm
表面積
200 m2/g
表面被覆率
3.5 μmol/m2
不純物
<10 ppm metals
マトリックス
silica gel, high purity, spherical base material
fully porous particle
マトリックス活性基
cyano phase
粒径
5 μm
ポアサイズ
180 Å
operating pH range
2-8
アプリケーション
food and beverages
分離法
hydrophilic interaction (HILIC)
normal phase
reversed phase
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関連するカテゴリー
特徴および利点
- 疎水性分析対象物の迅速な溶出に要する疎水性の低さ
- 優れたピ-ク形状および強塩基性分析対象物の保持
- 極性分析対象物の保持
- 独自の選択性
- C18カラムよりも顕著に低い保持(低濃度の有機系移動相が必要)
- 安定で低ブリ-ドのLC-MS分離
- 水系有機溶媒の濃度が高い移動相で使用可能
法的情報
Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany
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E F Nemeth et al.
The Journal of pharmacology and experimental therapeutics, 299(1), 323-331 (2001-09-19)
Despite the discovery of many ions and molecules that activate the Ca2+ receptor, there are no known ligands that block this receptor. Reported here are the pharmacodynamic properties of a small molecule, NPS 2143, which acts as an antagonist at
S L Able et al.
British journal of pharmacology, 162(2), 405-414 (2010-09-16)
The P2X7 receptor is implicated in inflammation and pain and is therefore a potential target for therapeutic intervention. Here, the development of a native tissue radioligand binding, localization and ex vivo occupancy assay for centrally penetrant P2X7 receptor antagonists is
Thomas J Woltering et al.
Bioorganic & medicinal chemistry letters, 18(3), 1091-1095 (2007-12-22)
A series of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives was evaluated as non-competitive mGluR2/3 antagonists. Replacement of a cyano group by a five-membered heterocycle produced compounds inhibiting the binding of [(3)H]-LY354740 to rat mGluR2 with low nanomolar affinity and consistent functional effect at both
Fan Zhang et al.
European journal of medicinal chemistry, 46(7), 3149-3157 (2011-04-26)
A series of novel 2-amino-3-cyano-6-(1H-indol-3-yl)-4-phenylpyridine derivatives were synthesized and their cytotoxic activity against A549, H460, HT-29 and SMMC-7721 cell lines was evaluated in vitro. Among them, ten compounds (10, 11, 14, 16, 17, 26, 27, 29, 30 and 31) displayed
Graciela B Arhancet et al.
Journal of medicinal chemistry, 53(16), 5970-5978 (2010-08-03)
A new 1,4-dihydropyridine 5a, containing a cyano group at the C3 position, was recently reported to possess excellent mineralocorticoid receptor (MR) antagonist in vitro potency and no calcium channel-blocker (CCB) activity. In the present study, we report the structure-activity relationships
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