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product name
Astec® CHIROBIOTIC® T Chiral HPLC Column, 5 μm particle size, L × I.D. 15 cm × 2.1 mm
物質
stainless steel column
認証
suitable for USP L63
詳細
HPLC column
製品種目
Astec®
包装
pkg of 1 ea
メーカー／製品名
Astec®
パラメーター
0-45 °C temperature
241 bar pressure (3500 psi)
テクニック
HPLC: suitable
LC/MS: suitable
L × 内径
15 cm × 2.1 mm
マトリックス
High-purity silica gel particle platform
fully porous particle
マトリックス活性基
teicoplanin glycopeptide phase
粒径
5 μm
ポアサイズ
100 Å
operating pH range
3.8-6.8
分離法
chiral
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詳細
CHIROBIOTIC® TおよびT2にはキラル選択剤としてテイコプラニンが含まれます。これらのカラムにより、多数の分子クラスについて独自の選択性が得られ、α、β、γおよび環状アミノ酸、N-誘導体化アミノ酸、ヒドロキシカルボン酸、カルボン酸およびフェノールを含む酸性化合物、小ペプチド、中性芳香族分析物ならびに環状芳香族および脂肪族アミンを特異的に非誘導体化します。キラルクラウンエーテルまたはリガンド交換型CSPで通常得られる分離がCHIROBIOTIC® TおよびT2でも可能ですが、移動相が水-アルコールのようにはるかにシンプルです。さらに、既知のすべてのβブロッカー（アミノアルコール類）およびジヒドロクマリンについて分析が行われています。CHIROBIOTIC® TおよびT2は、結合化学および支持粒子の孔径の面で差異があり、選択性および分取能が異なります。
CHIROBIOTIC FAQ
CHIROBIOTICの参考文献目録
キラル製品文献
- 結合相：テイコプラニン
- 操作pH範囲3.8～6.8
- 粒径：5、10または16 μm
- 孔径：100 Å （CHIROBIOTIC®T）、または200 Å （CHIROBIOTIC® T2）
CHIROBIOTIC FAQ
CHIROBIOTICの参考文献目録
キラル製品文献
アプリケーション
- Chiral liquid chromatography-mass spectrometry (LC-MS/MS) method development for the detection of salbutamol in urine samples: This research highlights the application of Astec® CHIROBIOTIC® T Chiral HPLC Column in sports medicine, specifically in the sensitive and accurate detection of salbutamol, a performance-enhancing beta-agonist, using advanced chiral chromatography techniques (Chan et al., 2016).
- High-performance liquid chromatographic enantioseparation of 2-aminomono- and dihydroxycyclopentanecarboxylic and 2-aminodihydroxycyclohexanecarboxylic acids on macrocyclic glycopeptide-based phases: Demonstrating the utility of Astec® CHIROBIOTIC® T Chiral HPLC Column for enantiomeric purity assessment in pharmaceutical research, this study provides insights into the precise separation of complex amino acid derivatives critical for developing new therapeutic agents (Berkecz et al., 2009).
法的情報
Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC
Choose from one of the most recent versions:
Felikss Mutulis et al.
Bioorganic & medicinal chemistry, 15(17), 5787-5810 (2007-07-10)
Two hundred and ten tertiary amides were prepared on solid phase. Diamines were coupled to activated carboxylated Wang polymer, and the polymeric substituted benzyloxycarbonyl protected diamines obtained were reacted with aldehydes or ketones in trimethyl orthoformate giving resin attached Schiff
Balázs Visegrády et al.
Journal of biochemical and biophysical methods, 53(1-3), 15-24 (2002-10-31)
This contribution deals with comparative studies on the chiral separation of thiazide diuretics using cellulose tris(3,5-dimethylphenylcarbamate) (Chiralcel OD-RH), cellulose tris(4-methylbenzoate) (Chiralcel OJ-R) and teicoplanin (Chirobiotic T) phases. All columns showed good chiral recognition ability for this class of compounds. Out
Zahid Ali et al.
Journal of chromatography. A, 1052(1-2), 199-204 (2004-11-06)
The solvation parameter model is used to characterize the retention properties of a 3-aminopropylsiloxane-bonded (Alltima amino), three 3-cyanopropylsiloxane-bonded (Ultrasphere CN, Ultremex-CN and Zorbax SB-CN), a spacer bonded propanediol (LiChrospher DIOL) and a multifunctional macrocyclic glycopeptide (Chirobiotic T) silica-based stationary phases
M Sanghvi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 933, 37-43 (2013-07-23)
Due to the lack of sensitivity in current methods for the determination of fenoterol (Fen), a rapid LC-MS/MS method was developed for the determination of (R,R')-Fen and (R,R';S,S')-Fen in plasma and urine. The method was fully validated and was linear
P Jander et al.
Journal of chromatography. A, 919(1), 67-77 (2001-07-19)
The retention behaviour of the enantiomers of underivatized phenylglycine was studied on a Chirobiotic T column packed with amphoteric glycopeptide teicoplanin covalently bonded to the surface of silica gel. The retention and the selectivity of separation of the enantiomers increase
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