U2508

Ubiquitin Carrier Protein H2 human

• MDL番号: MFCD04041190
• UNSPSCコード: 12352202
• NACRES: NA.56

特性

• 由来生物: human
• 品質水準: 200
• リコンビナント: expressed in E. coli (GST-tagged)
• アッセイ: >95% (SDS-PAGE)
• 形状: solution
• 分子量: ~14 kDa
• UniProtアクセッション番号: P61088; P62256
• アプリケーション: cell analysis
• 輸送温度: dry ice
• 保管温度: −70°C
• 遺伝子情報: human ... UBE2H(7328) , UBE2N(7334)

詳細

生物化学的／生理学的作用

UbcH2 is the human homolog to the yeast DNA repair gene RAD6 and is inducible by DNA damaging agents. Also associated with cancer-induced cachexia and the degradation of "N-end rule" substrates. UbcH2 mRNA level in muscle has also been correlated with sepsis. Moreover, c-Jun and c-Fos transcription factors have been shown to be ubiquitinated by an UbcH2-mediated event.

UbcH2 is the human homolog to the yeast DNA repair gene RAD6 and is inducible by DNA damaging agents. Also associated with cancer-induced cachexia and the degradation of "N-end rule" substrates. UbcH2 mRNA level in muscle has also been correlated with sepsis. Moreover, c-Jun and c-Fos transcription factors have been shown to be ubiquitinated by an UbcH2-mediated event. TNF-α was shown to stimulate expression of UbcH2 in skeletal muscle cells by increasing binding of NFκ-B to the promoter region of UbcH2, inducing transcription.

物理的形状

Solution in 50 mM HEPES, 50 mM NaCl, 10% glycerol, 1mM DTT, pH 7.8

その他情報

manufactured for Sigma by Boston Biochem. Inc.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable