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由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
buffered aqueous solution
化学種の反応性
rat
テクニック
western blot (chemiluminescent): 1:200 using rat brain membranes
UniProtアクセッション番号
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... KCNK2(3776)
rat ... Kcnk2(170899)
詳細
Potassium two pore domain channel subfamily K member 2 (KCNK2), also known as TWIK-related K+ channel-1 (TREK1), is expressed in the spinal cord, bladder and dorsal root ganglion. It is part of the TREK family.
特異性
The antibody reacts with rat TREK-1 (confirmed). It is expected that the antibody will also react with human and mouse TREK-1 due to sequence homology (17/18).
免疫原
synthetic peptide (DPKSA AQNSK PRLSF STKC) corresponding to the intracellular, amino terminus of human TREK-1 (amino acid residues 8-28).
アプリケーション
Anti-TREK-1 antibody produced in rabbit has been used in western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
生物化学的／生理学的作用
Potassium two pore domain channel subfamily K member 2 (KCNK2) possesses a potassium channel activity. It has a role in stabilizing the resting membrane potential of cells. The protein is also involved in the development of rat heart. TREK-1 could act as a drug target to treat acute heart ischemia.
物理的形状
Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
12 - Non Combustible Liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
T6448-50UL:
T6448-200UL:
T6448-BULK:
T6448-200UL-PW:
T6448-VAR:
T6448-50UL-PW:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Analysis of gene expression profiles in the programmed cell death rat retinal ganglion cells (RGC-5).
Abdelnaby K, et al.
Cancer Therapy, 6(2) (2008)
Naaz Andharia et al.
Channels (Austin, Tex.), 11(3), 224-235 (2017-01-14)
The TREK-1 channel, the TWIK-1-related potassium (K
Effects of fluoxetine on protein expression of potassium ion channels in the brain of chronic mild stress rats
Chunlin C, et al.
Acta Pharmaceutica Sinica. B, 5(1), 55-61 (2015)
Increased Expression of TREK-1 K+ Channel in the Dorsal Root Ganglion of Rats with Detrusor Overactivity After Partial Bladder Outlet Obstruction
Junlong Z,et al.
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 24, 1064-1064 (2018)
Chunlin Chen et al.
Acta pharmaceutica Sinica. B, 5(1), 55-61 (2015-11-19)
The purpose of this study is to investigate the expression of major potassium channel subtypes in the brain of chronical mild stress (CMS) rats and reveal the effects of fluoxetine on the expression of these channels. Rats were exposed to
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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