おすすめの製品
由来生物
mouse
結合体
unconjugated
抗体製品の状態
purified from hybridoma cell culture
抗体製品タイプ
primary antibodies
クローン
1C9-2, monoclonal
フォーム
buffered aqueous solution
分子量
antigen 22 kDa
交差性
human, monkey
以下との反応禁止
rodent
濃度
~1 mg/mL
テクニック
immunocytochemistry: suitable
microarray: suitable
western blot: 0.5-1.0 μg/mL using whole extract of cultured human lymphoma Raji cells.
アイソタイプ
IgG1
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... TOMM22(56993)
詳細
Translocase of outer mitochondrial membrane 22 (TOMM22) is an essential receptor of the mitochondrial import channel. It is characterized with an N-terminal negatively charged region exposed to the cytosol, a putative transmembrane region and a C-terminal intermembrane space region with little negative charge.
免疫原
membrane fraction from Vero (monkey kidney-derived) cells.
アプリケーション
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
- Western blotting
生物化学的／生理学的作用
Translocase of outer mitochondrial membrane 22 (TOMM22) is a key constituent of TOM complex. It functions as a mitochondrial receptor for the proapoptotic protein Bax (BCL2-associated X protein). TOMM22 interacts with 3-β hydroxysteroid dehydrogenase 2 (3βHSD2) and converts pregnenolone-to-progesterone in steroidogenic cells.
物理的形状
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
T6319-BULK:
T6319-VAR:
IXO97039:
T6319-.2ML:
最新バージョンのいずれかを選択してください：
TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax.
Bellot G, et al.
Cell Death and Differentiation, 14(4), 785-785 (2007)
An outer mitochondrial translocase, Tom22, is crucial for inner mitochondrial steroidogenic regulation in adrenal and gonadal tissues.
Rajapaksha M, et al.
Molecular and Cellular Biology, 36(6), 1032-1047 (2016)
Andrey Aristov et al.
Nature communications, 9(1), 2409-2409 (2018-06-21)
Single molecule localization microscopy can generate 3D super-resolution images without scanning by leveraging the axial variations of normal or engineered point spread functions (PSF). Successful implementation of these approaches for extended axial ranges remains, however, challenging. We present Zernike Optimized Localization
Increased interaction between DJ-1 and the Mi-2/nucleosome remodelling and deacetylase complex during cellular stress.
Opsahl J A., et al.
Proteomics, 10(7), 1494-1504 (2010)
Anna-Maria Joseph et al.
PloS one, 8(7), e69327-e69327 (2013-08-13)
Mitochondrial DNA (mtDNA) mutations lead to decrements in mitochondrial function and accelerated rates of these mutations has been linked to skeletal muscle loss (sarcopenia). The purpose of this study was to investigate the effect of mtDNA mutations on mitochondrial quality
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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