SRP8039

Irisin

recombinant, expressed in CHO cells, FLAG^® tagged, >95% (SDS-PAGE)

• 別名: CD121a, Fibronectin type III domain-containing protein 5 (cleaved), Fibronectin type III repeat-containing protein 2 (cleaved)
• CAS番号: 1465928-51-1
• UNSPSCコード: 12352202
• NACRES: NA.32

特性

• リコンビナント: expressed in CHO cells
• タグ: FLAG^® tagged
• アッセイ: >95% (SDS-PAGE)
• 形状: lyophilized
• 分子量: ~26 kDa
• 包装: pkg of 10 μg
• 不純物: <0.1 EU/μg endotoxin, tested
• UniProtアクセッション番号: Q8NAU1
• 輸送温度: wet ice
• 保管温度: −20°C
• 遺伝子情報: human ... FNDC5(252995)

詳細

詳細

Irisin is an described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin is cleaved from the type I membrane protein FNDC5 (fibronectin type III domain containing 5). FNDC5 is mainly expressed in the muscles. Low levels of the mRNA are also present in the kidney, liver and lung. The gene encoding irisin is mapped to human chromosome 1p35.1.

生物化学的／生理学的作用

Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin) and improves systemic metabolism by increasing energy expenditure. It is mainly responsible for the conversion of white fat into brown fat. This conversion enhances metabolic uncoupling and caloric expenditure. Irisin is always associated with beneficial responses of exercise on cellular metabolism. In obese and type 2 diabetic patients, low levels of circulating irisin are characteristic of the adipose tissue and muscle.

物理的形状

凍結乾燥品(PBS)。

再構成

Reconstitute with 100 μL deionized water.

その他情報

Irisin (human, aa 16-127 /mouse, aa 29-140) is Flag-tagged at the N-terminus. Irisin has 100% identity betwen mouse, rat, monkey and human.

法的情報

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable