SRP5335

PP2C-α, active, GST tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• 別名: FLJ42306, MGC9201, PP2C-ALPHA, PP2CA, PPM1A
• CAS番号: 362690-38-8
• UNSPSCコード: 12352200
• NACRES: NA.32

特性

• 由来生物: human
• リコンビナント: expressed in baculovirus infected Sf9 cells
• アッセイ: ≥70% (SDS-PAGE)
• 形状: buffered aqueous glycerol solution
• 比活性: 960-1440 nmol/min·mg
• 分子量: ~105 kDa
• NCBIアクセッション番号: NM_021003
• アプリケーション: cell analysis
• 輸送温度: dry ice
• 保管温度: −70°C
• 遺伝子情報: human ... PPM1A(5494)

詳細

詳細

Protein phosphatase 2C-α (PP2C-α), also called protein phosphatase, Mg²⁺/Mn²⁺ dependent 1A (PPM1A), is a member of the family of Ser/Thr protein phosphatases and is composed of a catalytic subunit and a constant regulatory subunit. PP2C-α is highly expressed in heart and skeletal muscle. The gene encoding this protein is localized on human chromosome 4q12.

生物化学的／生理学的作用

Protein phosphatase 2C-α (PP2C-α) or PPM1A is known to be negative regulators of cell stress response pathways. It has been reported to negatively regulate TGF-β signaling pathway and cell cycle. PP2C-α has been shown to dephosphorylate cyclin-dependent kinases (CDKs) and it may be involved in cell cycle control. It modulates cell migration and invasion. Overexpression of PP2C-α is reported to cause cell-growth arrest or cell death.

物理的形状

50 mM Tris-HCl溶液（pH 7.5、150 mM NaCl、10 mM グルタチオン、0.1 mM EDTA、0.25 mM DTT、0.1 mM PMSF、25％ グリセロール）

調製ノート

開封後は少量ずつに分注して－70℃で保管してください。操作を反復したり凍結融解を何度も繰り返したりしないでください。

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable