SRP0311

HDAC6 H611A human

recombinant, expressed in baculovirus infected Sf9 cells, ≥79% (SDS-PAGE)

• 別名: HD6, JM21, histone deacetylase 6
• UNSPSCコード: 12352200
• NACRES: NA.32

特性

• 由来生物: human
• リコンビナント: expressed in baculovirus infected Sf9 cells
• アッセイ: ≥79% (SDS-PAGE)
• 形状: aqueous solution
• 分子量: 161 kDa
• 包装: pkg of 50 μg
• NCBIアクセッション番号: NM_006044
• UniProtアクセッション番号: Q9UBN7
• 輸送温度: dry ice
• 保管温度: −70°C
• 遺伝子情報: human ... HDAC6(10013)

詳細

詳細

HDAC6 (histone deacetylase 6) belongs to the HDAC family of proteins. HDACs are responsible for deacetylation of nuclear histone and nonhistone proteins, including transcription factors. The mutation H611A results in catalytically inactive HDAC6.
Human HDAC6 with H611A mutation (GenBank Accession No. NM_006044), full length with N-terminal GST tag, MW= 161kDa, expressed in a Baculovirus expression system.

生物化学的／生理学的作用

HDAC6 (histone deacetylase 6) is involved in the control of microtubules, growth factor-mediated chemotaxis, stress response in presence of misfolded protein and tumor invasion. It also participates in EGF (epidermal growth factor)-mediated β-catenin nuclear presence and activation of c-myc. In mouse model, HDAC6 is implicated in oncogene-induced tumorigenesis. HDAC6 is the main deacetylase for α-tubulin and thus, is involved in cell motility. It is also involved in the formation of SGs (stress granules) and SG proteins. Mutations in the 3′-UTR of the HDAC6 gene suppresses hsa-miR-433-mediated post-transcriptional regulation. This results in overexpression of HDAC6, thereby causing X-linked chondrodysplasia.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable