SML3697

Anagliptin

≥98% (HPLC)

• 別名: (S)-N-(2-(2-(2-Cyanopyrrolidin-1-yl)-2-oxoethylamino)-2-methylpropyl)-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide, N-[2-({2-[(2S)-2-Cyanopyrrolidine-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide, SK 0403, SK-0403, SK0403
• 実験式（ヒル表記法）: C₁₉H₂₅N₇O₂
• CAS番号: 739366-20-2
• 分子量: 383.45
• MDL番号: MFCD19443729
• UNSPSCコード: 51111800
• UNSPSCコード: 12352200
• NACRES: NA.21

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: -10 to -25°C
• SMILES記法: [n]21nc(cc2ncc(c1)C(=O)NCC(NCC(=O)N3[C@@H](CCC3)C#N)(C)C)C
• InChI: 1S/C19H25N7O2/c1-13-7-16-21-9-14(11-26(16)24-13)18(28)22-12-19(2,3)23-10-17(27)25-6-4-5-15(25)8-20/h7,9,11,15,23H,4-6,10,12H2,1-3H3,(H,22,28)/t15-/m0/s1
• InChI Key: LDXYBEHACFJIEL-HNNXBMFYSA-N

詳細

生物化学的／生理学的作用

Anagliptin is an orally active, potent and selective dipeptidyl peptidase 4 (DPP-IV; DPP4) inhibitor (DPP4/8/9 IC50 = 3.8/68/60 nM). When administered in vivo (0.3% w/w in diet), anagliptin shows anti-atherosclerotic efficay in apoE-deficient mice and ameliorates diabetes in mice with haploinsufficiency of glucokinase on a high-fat diet.

Orally active, potent and selective dipeptidyl peptidase 4 (DPP-IV; DPP4) inhibitor with anti-atherosclerotic and anti-diabetic efficacy in vivo.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable