SML3388

Vortioxetine hydrobromide

≥98% (HPLC)

• 別名: 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine hydrobromide, Lu AA21004 HBr, Lu AA21004 hydrobromide, Vortioxetine HBr
• 実験式（ヒル表記法）: C₁₈H₂₂N₂S·HBr
• CAS番号: 960203-27-4
• 分子量: 379.36
• MDL番号: MFCD22383961
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 保管条件: desiccated
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: 2-8°C
• InChI: 1S/C18H22N2S.BrH/c1-14-7-8-17(15(2)13-14)21-18-6-4-3-5-16(18)20-11-9-19-10-12-20;/h3-8,13,19H,9-12H2,1-2H3;1H
• InChI Key: VNGRUFUIHGGOOM-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

Vortioxetine (Lu AA21004) is an orally active, multimodal serotonergic compound with high affinity toward human 5-HT1A (Ki = 15 nM), 5-HT1B (Ki = 33 nM), 5-HT1D (Ki = 54 nM), 5-HT3A (Ki = 3.7 nM), 5-HT7 (Ki = 19 nM), noradrenergic β1 (Ki = 46 nM) receptors, and serotonin (5-HT) transporter (SERT Ki = 1.6 nM). Vortioxetine exhibits in vivo psychotropic efficacy by exerting antagonist activity against 5-HT-1D/3A/7, agonist activity on 5-HT1A, partial agonist activity on 5-HT1B, as well as potent SERT inhibitory activity.

安全性情報

• ピクトグラム: GHS08,GHS09
• シグナルワード: Warning
• 危険有害性情報: H361d,H373,H410
• 注意書き: P202 - P260 - P273 - P280 - P308 + P313 - P391
• 危険有害性の分類: Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - STOT RE 2
• ターゲットの組織: Kidney
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable