SML2800

Proscillaridin A

≥90% (HPLC)

• 別名: Proscillaridin A, (3β)-3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-14-hydroxybufa-4,20,22-trienolide, 3-(6-Deoxy-α-L-mannopyranosyloxyl)-14-hydroxybufa-4,20,22-trienolide, Scillarenin 3β-rhamnoside
• 実験式（ヒル表記法）: C₃₀H₄₂O₈
• CAS番号: 466-06-8
• 分子量: 530.65
• MDL番号: MFCD00214065
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥90% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: −20°C
• SMILES記法: C[C@]12CC[C@]3([H])[C@@]4(C)CC[C@H](O[C@]5([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)C=C4CC[C@@]3([H])[C@@]1(O)CC[C@@H]2C6=COC(C=C6)=O
• InChI: 1S/C30H42O8/c1-16-24(32)25(33)26(34)27(37-16)38-19-8-11-28(2)18(14-19)5-6-22-21(28)9-12-29(3)20(10-13-30(22,29)35)17-4-7-23(31)36-15-17/h4,7,14-16,19-22,24-27,32-35H,5-6,8-13H2,1-3H3/t16-,19?,20?,21?,22?,24-,25+,26+,27-,28?,29?,30?/m0/s1
• InChI Key: MYEJFUXQJGHEQK-RLQJMXQZSA-N

詳細

生物化学的／生理学的作用

Proscillaridin A, a cardiac glycoside, is an antiarrhythmic drug that enhances DNMT inhibitors and HDAC inhibitors activity. Combination of decitabine with proscillaridin A produced profound gene expression reprogramming associated with down-regulation of 153 epigenetic regulators including SYMD3 and KDM8. Proscillaridin A was recently identified as a potent anti-HBV agent (IC50 = 7.2?nM).

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H301
• 注意書き: P264 - P270 - P301 + P310 - P405 - P501
• 危険有害性の分類: Acute Tox. 3 Oral
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3