SML2516

Valrubicin

• 別名: Trifluoroacetyladriamycin 14-valerate
• 実験式（ヒル表記法）: C₃₄H₃₆F₃NO₁₃
• CAS番号: 56124-62-0
• 分子量: 723.64
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 形状: powder or crystals
• 保管温度: 2-8°C
• InChI: 1S/C34H36F3NO13/c1-4-5-9-21(40)49-13-20(39)33(47)11-16-24(19(12-33)51-22-10-17(27(41)14(2)50-22)38-32(46)34(35,36)37)31(45)26-25(29(16)43)28(42)15-7-6-8-18(48-3)23(15)30(26)44/h6-8,14,17,19,22,27,41,43,45,47H,4-5,9-13H2,1-3H3,(H,38,46)/t14?,17?,19-,22?,27?,33-/m0/s1
• InChI Key: ZOCKGBMQLCSHFP-ZQUOIQDWSA-N

詳細

生物化学的／生理学的作用

Valrubicin is a semisynthetic derivative of the antineoplastic anthracycline antibiotic doxorubicin. Valrubicin is converted intracytoplasmically into N-trifluoroacetyladriamycin, which interacts with topoisomerase II, stabilizing the complex between the enzyme and DNA and causing cell cycle arrest.

安全性情報

• ピクトグラム: GHS08,GHS07
• シグナルワード: Danger
• 危険有害性情報: H302,H340,H350,H360F
• 注意書き: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• 危険有害性の分類: Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable