SML2500

Senicapoc

≥98% (HPLC)

• 別名: 4-fluoro-α-(4-fluorophenyl)-α-phenyl-Benzeneacetamide, ICA 17043
• 実験式（ヒル表記法）: C₂₀H₁₅F₂NO
• CAS番号: 289656-45-7
• 分子量: 323.34
• MDL番号: MFCD09027349
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: O=C(N)C(C1=CC=C(F)C=C1)(C2=CC=C(F)C=C2)C3=CC=CC=C3
• InChI: 1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)
• InChI Key: SCTZUZTYRMOMKT-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

Senicapoc (ICA-17043) is an inhibitor of the calcium-activated K⁺ channel KCa3.1, also known as the Gardos channel, which plays a role in K⁺ loss and dehydration of sickled red blood cells. Senicapoc blocks calcium-induced rubidium flux in human RBCs with and IC50 of 11 nM and prevents RBC dehydration in a transgenic mouse sickle cell disease model. It has been investigated for a number of possible uses, which include antimalarial activity, idiopathic pulmonary fibrosis, glioblastoma, lung cancer, non-alcoholic liver disease, hereditary xerocytosis, suppression of microglial activation in stroke, and immune system disorders.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable