SML2343

SGC3027

≥98 mg/mL (HPLC)

• 別名: SGC3027, 5′-S-[4-[(N-(3-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-3-methyl)butyryl)-(N-(4′-chloro-biphenyl-3-ylmethyl)amino]butyl]-5′-thioadenosine, N-(4-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)thio)butyl)-N-((4′-chloro-[1,1′-biphenyl]-3-yl)methyl)-3-methyl-3-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide
• 実験式（ヒル表記法）: C₄₁H₄₇ClN₆O₆S
• CAS番号: 2624313-13-7
• 分子量: 787.37
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 形状: powder
• 濃度: ≥98 mg/mL (HPLC)
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: −20°C
• SMILES記法: ClC(C=C1)=CC=C1C2=CC(CN(C(CC(C)(C)C(C(C(C)=C3C)=O)=C(C)C3=O)=O)CCCCSC[C@H]4O[C@@H](N(C=N5)C6=C5C(N)=NC=N6)[C@H](O)[C@@H]4O)=CC=C2

詳細

生物化学的／生理学的作用

SGC3027 is a selective and cell-active inhibitor of protein arginine N-methyltransferase (PRMT7) It is a pro-drug of the active component, SGC8158, which is produced in the cell by reductases. SGC8158 was shown to inhibit PRMT7 with an IC50 value < 2.5 nM for methylation of H2B (23-37) and greater than 40-fold selectivity over other histone methyltransferases and non-epigenetic targets. SGC3027 inhibited the methylation of HSP70 In cellular assays using C2C12 cells with an IC50 value of 1.3 microM. The closely related SGC3027N is significantly less active in the cellular assay, and is a control compound for cellular studies.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable