SML1584

CMPPE

≥95% (HPLC)

• 別名: 2-[1-[2-(4-Chlorophenyl)-5-methylpyrazol[1,5-a]pyrimidin-7-yl]-2-piperidinyl]ethanol
• 実験式（ヒル表記法）: C₂₀H₂₃ClN₄O
• CAS番号: 841253-81-4
• 分子量: 370.88
• MDL番号: MFCD05710220
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825972
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: powder
• 色: white to light brown
• 溶解性: DMSO: 5 mg/mL, clear (warmed)
• 保管温度: 2-8°C
• SMILES記法: ClC(C=C1)=CC=C1C2=NN(C(N3C(CCO)CCCC3)=CC(C)=N4)C4=C2
• InChI: 1S/C20H23ClN4O/c1-14-12-20(24-10-3-2-4-17(24)9-11-26)25-19(22-14)13-18(23-25)15-5-7-16(21)8-6-15/h5-8,12-13,17,26H,2-4,9-11H2,1H3
• InChI Key: TZWSGOPCLUTFBZ-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

CMPPE is a GABAB receptor positive allosteric modulator (PAM). GABAB receptor positive allosteric modulators have potential for treatment of many neuro-psychiatric disorders as well as drug dependence and seizures. The receptor is a GPCR expressed throughout the CNS; it acts as both an auto-receptor and heteroreceptor to mudulate GABA release and regulate K+ channels and Ca++ channels. CMPPE has the highest hypoactivity/anticonvulsant ratio.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 注意書き: P264 - P270 - P301 + P312 - P501
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable