SML1542

Sitamaquine tosylate

≥98% (HPLC)

• 別名: 6-Methoxy-8-(6-diethylaminohexylamine)-4-methylquinoline tosylate, N-[6-(Diethylamino)hexyl]-6-methoxy-4-methylquinolin-8-amine tosylate, N1,N1-Diethyl-N6-(6-methoxy-4-methyl-8-quinolinyl)-1,6-hexanediamine tosylate, NSC 2452, WR-6026
• 実験式（ヒル表記法）: C₂₁H₃₃N₃O · C₇H₈O₃S
• CAS番号: 1019640-33-5
• 分子量: 515.71
• MDL番号: MFCD17392572
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825952
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: H₂O: 15 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: CC1=C(C=C(OC)C=C2NCCCCCCN(CC)CC)C2=NC=C1.CC3=CC=C(S(=O)(O)=O)C=C3
• InChI: 1S/C21H33N3O.C7H8O3S/c1-5-24(6-2)14-10-8-7-9-12-22-20-16-18(25-4)15-19-17(3)11-13-23-21(19)20;1-6-2-4-7(5-3-6)11(8,9)10/h11,13,15-16,22H,5-10,12,14H2,1-4H3;2-5H,1H3,(H,8,9,10)
• InChI Key: LOBPWLFCZDGYKW-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

Sitamaquine is also known as WR-6026. It is used in the treatment of visceral leishmaniasis.

Sitamaquine is an orally active 8-aminoquinoline analog that exhibit antiplasmodial and antileishmanial activities. Sitamaquine accumulates in Leishmania parasites. Sitamaquine potently inhibits respiratory chain complex II (succinate dehydrogenase), which leads to an apoptosis-like death of Leishmania parasites.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3