SML1237

CCT137690

≥98% (HPLC)

• 別名: 6-Bromo-7-[4-[(5-methyl-3-isoxazolyl)methyl]-1-piperazinyl]-2-[4-(4-methyl-1-piperazinyl)phenyl]-3H-imidazo[4,5-b]pyridine
• 実験式（ヒル表記法）: C₂₆H₃₁BrN₈O
• CAS番号: 1095382-05-0
• 分子量: 551.48
• MDL番号: MFCD18206879
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825737
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear (warmed)
• 保管温度: −20°C
• SMILES記法: CN(CC1)CCN1C(C=C2)=CC=C2C3=NC4=C(N5CCN(CC6=NOC(C)=C6)CC5)C(Br)=CN=C4N3
• InChI: 1S/C26H31BrN8O/c1-18-15-20(31-36-18)17-33-9-13-35(14-10-33)24-22(27)16-28-26-23(24)29-25(30-26)19-3-5-21(6-4-19)34-11-7-32(2)8-12-34/h3-6,15-16H,7-14,17H2,1-2H3,(H,28,29,30)
• InChI Key: GFLQCBTXTRCREJ-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

CCT137690 is a very potent, orally bioavailble, pan aurora kinase inhbitor (IC₅₀ = 15, 25, and 19 nM for Aurora A, B and C respectively). CCT137690 inhibits tumor growth in amouse xenograft model and causes multipolar spindle formation, chromosome misalignment, polyploidy and apoptosis in tumor cell lines.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable