SML1002

Sinomenine hydrochloride

≥98% (HPLC)

• 別名: (9a,13a,14a)-7,8-Didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-morphinan-6-one hydrochloride, Cucoline hydrochloride, Kukolin hydrochloride
• 実験式（ヒル表記法）: C₁₉H₂₃NO₄ · HCl
• CAS番号: 6080-33-7
• 分子量: 365.85
• MDL番号: MFCD01714307
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 由来生物: plant (Sinomenium acutum)
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 光学活性: [α]/D -70 to -90°, c = 1 in H₂O
• 薬剤管理: regulated under CDSA - not available from Sigma-Aldrich Canada
• 色: white to beige
• 溶解性: H₂O: 20 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: OC1=C(OC)C=CC(C2)=C1[C@]3(CC(C(OC)=C4)=O)[C@@]4([H])[C@H]2N(C)CC3.Cl
• InChI: 1S/C19H23NO4.ClH/c1-20-7-6-19-10-14(21)16(24-3)9-12(19)13(20)8-11-4-5-15(23-2)18(22)17(11)19;/h4-5,9,12-13,22H,6-8,10H2,1-3H3;1H/t12-,13+,19-;/m1./s1
• InChI Key: YMEVIMJAUHZFMW-VUIDNZEBSA-N

詳細

生物化学的／生理学的作用

Sinomenine is a herbal medicine used to treat inflammatory diseases like rheumatoid arthritis. Sinomenine had anti-inflammatory effects in several animal models of inflammation, and inhibits mast cell degranulation and histamine release. Additionally, Sinomenine potentiates renewal of human embryonic stem cells.

安全性情報

• ピクトグラム: GHS08,GHS07
• シグナルワード: Warning
• 危険有害性情報: H302 + H312 + H332,H315,H319,H335,H351
• 注意書き: P201 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
• 危険有害性の分類: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable