SML0922

NSC130813

≥98% (HPLC)

• 別名: 4-[(6-Chloro-2-methoxy-9-acridinyl)amino]-2-[(4-methyl-1-piperazinyl)methyl]-phenol trihydrochloride, F06, NERI02
• 実験式（ヒル表記法）: C₂₆H₂₇ClN₄O₂ · 3HCl
• CAS番号: 1082532-95-3
• 分子量: 572.35
• UNSPSCコード: 51111800
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: yellow to orange
• 溶解性: H₂O: 10 mg/mL, clear
• 保管温度: −20°C

詳細

生物化学的／生理学的作用

NSC130813 blocks protein-protein interactions between XPF and ERCC1, two proteins involved in nucleotide excision repair (NER). The compound, NSC130813, blocks repair of DNA damage induced by platinum-based ctyotoxic drugs and DNA alkylating agents. NSC130813 synergistically potentiates cell death in cancer cell lines treated with cisplatin or mitomycin C.

NSC130813 is a Xeroderma Pigmentosa Group F (XPF) antagonist, inhibitor of nucleotide excision repair (NER) mechanism.

その他情報

air sensitive

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable