SML0842

CRANAD 2

≥98% (HPLC)

• 別名: (T-4)-[(1E,6E)-1,7-bis[4-(Dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-?O3,?O5]difluoroboron
• 実験式（ヒル表記法）: C₂₃H₂₅BF₂N₂O₂
• CAS番号: 1193447-34-5
• 分子量: 410.26
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 保管条件: desiccated
• 色: , dark blue to black
• 溶解性: DMSO: 0.2 mg/mL, clear (warmed)
• 保管温度: 2-8°C
• SMILES記法: [B-]1([O+]=C(C=C(O1)\C=C\c3ccc(cc3)N(C)C)\C=C\c2ccc(cc2)N(C)C)(F)F
• InChI: 1S/C23H25BF2N2O2/c1-27(2)20-11-5-18(6-12-20)9-15-22-17-23(30-24(25,26)29-22)16-10-19-7-13-21(14-8-19)28(3)4/h5-17H,1-4H3/b15-9+,16-10+
• InChI Key: PVXQJYXODFZTBR-KAVGSWPWSA-N

詳細

生物化学的／生理学的作用

CRANAD 2 is a near-infrared (NIR) Aβ plaque-specific fluorescent probe.

CRANAD 2 is a near-infrared (NIR) Aβ plaque-specific fluorescent probe. CRANAD 2 penetrates the blood brain barrier and has a high affinity for Aβ aggregates with a Kd of 38 nM. Upon interacting with Aβ aggregates, CRANAD 2 exhibits a 70-fold increase in fluorescence intensity accompanied by a 90 nm blue shift from 805 to 715 nm and a large increase in quantum yield. CRANAD 2 has been used to detect Aβ deposits noninvasively in vivo in transgenic Tg2576 mice.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319
• 注意書き: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable