SML0681

Febrifugine dihydrochloride

≥95% (HPLC)

• 別名: 3-[3-[(2R,3S)-3-Hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone dihydrochloride
• 実験式（ヒル表記法）: C₁₆H₁₉N₃O₃ · 2HCl
• CAS番号: 32434-42-7
• 分子量: 374.26
• UNSPSCコード: 51111800
• PubChem Substance ID: 329825583
• NACRES: NA.77

特性

• アッセイ: ≥95% (HPLC)
• フォーム: powder
• 光学活性: [α]/D 10 to 15°, c = 1 in H₂O
• 保管条件: desiccated
• 色: off-white to gray-brown
• 溶解性: H₂O: 15 mg/mL, clear
• 保管温度: −20°C
• SMILES記法: O=C1C2=CC=CC=C2N=CN1CC(C[C@@H]3[C@@H](O)CCCC3)=O.C
• InChI: 1S/C17H20N2O3.CH4/c20-13(9-12-5-1-4-8-16(12)21)10-19-11-18-15-7-3-2-6-14(15)17(19)22;/h2-3,6-7,11-12,16,21H,1,4-5,8-10H2;1H4/t12-,16+;/m1./s1
• InChI Key: SNTOTCUGCWLHEZ-KKJWGQAZSA-N

詳細

生物化学的／生理学的作用

Febrifugine dihydrochloride exhibits strong antimalarial activity against Plasmodium falciparum, the most insidious malaria causative agent. The adverse effects of febrifugine include diarrhoea, vomiting and liver toxicity.

Febrifugine is an antimalarial, the active component of the Chinese herb Chang Shan. Recent studies indicate that its mechanism of action is as an inhibitor of prolyl-transfer RNA synthetase (ProRS).

Febrifugine is an antimalarial, the active component of the Chinese herb Chang Shan; inhibitor of prolyl-transfer RNA synthetase (ProRS).

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 注意書き: P264 - P270 - P301 + P312 - P501
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable