SML0494

VU0361737

≥98% (HPLC)

• 別名: CID-44191096, ML128, N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide
• 実験式（ヒル表記法）: C₁₃H₁₁ClN₂O₂
• CAS番号: 1161205-04-4
• 分子量: 262.69
• MDL番号: MFCD16618402
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825444
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: film
• 色: white
• 溶解性: DMSO: 15 mg/mL (clear solution)
• 保管温度: 2-8°C
• SMILES記法: COc1cc(NC(=O)c2ccccn2)ccc1Cl
• InChI: 1S/C13H11ClN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)
• InChI Key: ARYUXFNGXHNNDM-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

VU0361737 is an mGluR4-specific positive allosteric modulator (PAM) with greater than 50 fold selectivity over other mGluR subtypes. The EC₅₀ values for human and rat mGlu4 are 240 and 110 nM, respectively, compared to greater than 10 mM for all other mGluRs.

特徴および利点

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302,H319
• 注意書き: P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501
• 危険有害性の分類: Acute Tox. 4 Oral - Eye Irrit. 2
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable