SML0374

U-104

≥98% (HPLC)

• 別名: 4-[[[(4-Fluorophenyl)amino]carbonyl]amino]-benzenesulfonamide, NSC 213841
• 実験式（ヒル表記法）: C₁₃H₁₂FN₃O₃S
• CAS番号: 178606-66-1
• 分子量: 309.32
• MDL番号: MFCD00159265
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825375
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: >15 mg/mL
• 保管温度: 2-8°C
• SMILES記法: O=C(NC1=CC=C(S(N)(=O)=O)C=C1)NC2=CC=C(F)C=C2
• InChI: 1S/C13H12FN3O3S/c14-9-1-3-10(4-2-9)16-13(18)17-11-5-7-12(8-6-11)21(15,19)20/h1-8H,(H2,15,19,20)(H2,16,17,18)
• InChI Key: YJQZNWPYLCNRLP-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

U-104 is an inhibitor of CA IX that binds only to CA IX under hypoxic conditions in vivo. The binding results in significant inhibition of tumor growth and metastasis formation in both spontaneous and experimental models of metastasis. U-104 reduces the medium acidity by inhibiting the catalytic activity of the CA IX. It binds specifically only to hypoxic cells expressing CA IX.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable