SCP0252

トロンビン基質、蛍光発生基質

• 実験式（ヒル表記法）: C₃₁H₄₂N₇O₇
• 分子量: 624.71
• UNSPSCコード: 12352202
• NACRES: NA.32

特性

• アッセイ: ≥95% (HPLC)
• フォーム: lyophilized
• 組成: Peptide Content, ≥80%
• 保管条件: protect from light
• 保管温度: −20°C

詳細

Amino Acid Sequence

BOC-Val-Pro-Arg-AFC

詳細

Thrombin has procoagulant and anticoagulant properties. It also has chemotactic and mitogenic effects. Thrombin triggers the growth of mammalian cells, fibroblasts and macrophage- like tumor cell lines. It regulates brain development. Thrombin plays an important role in hemostasis and thrombosis. It is associated with mast cell degranulation along with the release of histamine and enhances the production of IL-1 (interleukin-1) by activated macrophages. Thrombin stimulates vascular permeability and transendothelial cell migration by neutrophils.

アプリケーション

Thrombin is a serine protease involved in the coagulation cascade wherein it converts fibrinogen into fibrin. Thrombin may be detected (assayed) using peptides that contain the VPR sequence such as the fluorogenic substrates Boc-VPR-AFC, Boc-Val-Pro-Arg-7-AMC and the chromogenic substrate Boc-Val-Pro-Arg-pNA. These substrates may also be useful to detect other serine proteases.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable