SBR00037

Solithromycin

≥98% (HPLC)

• 別名: 2H-Oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone, CEM-101, OP-1068
• 実験式（ヒル表記法）: C₄₃H₆₅FN₆O₁₀
• 分子量: 845.01
• MDL番号: MFCD30207880
• UNSPSCコード: 51102829
• NACRES: NA.76

特性

• 品質水準: 200
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to off-white
• 抗生物質活性スペクトル: Gram-negative bacteria; Gram-positive bacteria
• 作用機序: protein synthesis | interferes
• 保管温度: −20°C
• SMILES記法: F[C@@]1(C(=O)O[C@@H]([C@]2(OC(=O)N([C@@H]2[C@H](C(=O)[C@@H](C[C@]([C@@H]([C@H](C1=O)C)O[C@@H]5O[C@@H](C[C@@H]([C@H]5O)N(C)C)C)(OC)C)C)C)CCCC[n]3nnc(c3)c4cc(ccc4)N)C)CC)C
• InChI: 1S/C43H65FN6O10/c1-12-32-43(8)35(50(40(55)60-43)19-14-13-18-49-23-30(46-47-49)28-16-15-17-29(45)21-28)26(4)33(51)24(2)22-41(6,56-11)37(27(5)36(53)42(7,44)39(54)58-32)59-38-34(52)31(48(9)10)20-25(3)57-38/h15-17,21,23-27,31-32,34-35,37-38,52H,12-14,18-20,22,45H2,1-11H3/t24-,25-,26+,27+,31+,32-,34-,35-,37-,38+,41-,42+,43-/m1/s1
• InChI Key: IXXFZUPTQVDPPK-ZAWHAJPISA-N

詳細

詳細

Solithromycin is a highly potent next-generation macrolid. the first fluoroketolid. which has potent activity against most macrolide-resistant strains. Solithromycin (CEM-101) is a novel fluoroketolide with improved antimicrobial effectiveness.

アプリケーション

Solithromycin has been shown to have potentent activity against S. pneumoniae as well as an extended spectrum of activity against CA-MRS. enterococc according to in vitro and in vivo research. Solithromycin has been used in:

• the research on the anti-inflammatory effects of macrolides
• the research of potency of solithromycin in comparison to other antimicrobials
• in ithe research of the vitro activity of solithromycin against clinical N. gonorrhoeae isolates and reference strain

生物化学的／生理学的作用

Mode of Action: Solithromycin binds to the large 50S subunit of the ribosome and inhibits protein biosynthesis. Like other ketolide. it should impair bacterial ribosomal subunit formation.

Antimicrobial spectrum: Active against bacteria like Legionella, Chlamydophila, Chlamydia, Mycoplasma, and Ureaplasma and against gonococci and other organisms that cause genitourinary tract infections

特徴および利点

High quality antibiotic suitable for mulitple research applications

その他情報

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安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable