SAB5700620

Anti-CDKN2A/p16INK4a antibody produced in rabbit

• 別名: ARF, CDK4I, CDKN2, CDKN2A, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19
• UNSPSCコード: 12352203
• NACRES: NA.43

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: 11; 12; 13; 16; 17; 8
• 化学種の反応性: human, rat, mouse
• 濃度: 1.21 mg/ml
• テクニック: immunofluorescence: 1:50-1:200; immunohistochemistry: 1:50-1:200; western blot: 1:500-1:2000
• UniProtアクセッション番号: P42771; Q8N726
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... CDKN2A(1029)

詳細

詳細

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.

免疫原

A synthetic peptide corresponding to a sequence within amino acids 20 to the C-terminus of human CDKN2A / p16INK4a

物理的形状

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

保管および安定性

Store at -20℃. Avoid freeze / thaw cycles.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable