SAB5700388

Anti-Phospho-HER2/ERBB2-Y1221/1222 antibody produced in rabbit

• 別名: CD340, ERBB2, ErbB2, HER-2, HER-2/neu, HER2, HER2/ErbB2, MLN 19, MLN19, NEU, NGL, TKR1, erb-b2 receptor tyrosine kinase 2
• UNSPSCコード: 12352203
• NACRES: NA.43
• クローン: polyclonal
• application: WB
• 化学種の反応性: human
• テクニック: western blot: 1:500-1:1000

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: 134; 136; 137; 62; 70; 97
• 化学種の反応性: human
• 濃度: 5.8 mg/ml
• テクニック: western blot: 1:500-1:1000
• UniProtアクセッション番号: P04626
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: phosphorylation (pTyr1221/pTyr1222)
• 遺伝子情報: human ... ERBB2(2064)

詳細

詳細

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

免疫原

A synthetic phosphorylated peptide around Y1221 & Y1222 of human HER2/ERBB2 (NP_004439.2).

物理的形状

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

保管および安定性

Store at -20℃. Avoid freeze / thaw cycles.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable