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由来生物
rabbit
品質水準
リコンビナント
expressed in proprietary host
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
SP228, monoclonal
交差性
human (tested)
テクニック
flow cytometry: 1:100
immunohistochemistry: 1:100
アイソタイプ
IgG
UniProtアクセッション番号
輸送温度
wet ice
保管温度
2-8°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... HLA-DPA1(3113)
詳細
HLA-DP is an antigen receptor and one of the MHC class II proteins. HLA-DP is a heterodimer of an alpha and a beta chain. Both chains are type I transmembrane proteins with short cytoplasmic domains. It is expressed on antigen-presenting cells and a variety of other cell types, and is also expressed by various tumors such as melanoma, gastric carcinoma, breast carcinoma, ovarian carcinoma, and lymphoma.
Major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1) is a class II heterodimer comprising of a polymorphic β and an oligomorphic α chain. It is encoded by the gene mapped to human chromosome 6p21.33. HLA-DPA1 is generally expressed on a subset of Kupffer cells and resident macrophages in liver.
免疫原
Synthetic peptide derived from human HLA-DP alpha1 protein.
アプリケーション
Anti-HLA-DP alpha 1 antibody, Rabbit monoclonal has been used in immunohistochemistry.
生物化学的／生理学的作用
Major histocompatibility complex, class II, DP alpha 1 (HLA-DPA1) alloreactivity is highly relevant in clinical transplantation. It plays an essential role in the presentation of viral antigens to CD4+ T helper (Th) lymphocytes. Studies have suggested that SNP (single nucleotide polymorphisms) of HLA-DP can result in chronic hepatitis B virus (HBV) infection.
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
物理的形状
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SAB5500118-100UL:
最新バージョンのいずれかを選択してください：
HLA-DP Polymorphisms Affect the Outcomes of Chronic Hepatitis B Virus Infections, Possibly through Interacting with Viral Mutations
Zhang Q, et al.
Journal of Virology, 02073-02073 (2013)
Allorecognition of HLA-DP by CD4+ T cells is affected by polymorphism in its alpha chain.
Lauterbach N, et al.
Molecular Immunology, 59(1), 19-29 (2014)
New loci associated with chronic hepatitis B virus infection in Han Chinese.
Hu Z, et al.
Nature Genetics, 45(12), 1499-1499 (2013)
Studies on the association of single nucleotide polymorphisms of HLA-DP and DQ genes with the outcome of chronic hepatitis B virus infection
Su M, et al.
Zhonghua yi xue yi chuan xue za zhi (Chinese Journal of Medical Genetics), 31(6), 765-769 (2014)
Pulsed electrical stimulation benefits wound healing by activating skin fibroblasts through the TGF?1/ERK/NF-?B axis.
Wang Y, et al.
Biochimica et Biophysica Acta, 1860(7), 1551-1559 (2016)
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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