SAB5500113

Anti-Glial Fibrillary Acidic Protein Antibody

rabbit monoclonal, SP78

• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 製品名: Anti-GFAP antibody, Rabbit monoclonal, recombinant, expressed in proprietary host, clone SP78, affinity isolated antibody
• 由来生物: rabbit
• 品質水準: 100
• リコンビナント: expressed in proprietary host
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: SP78, monoclonal
• 交差性: human (tested)
• 交差性（ホモロジーによる予測）: mouse, bovine, dog, rabbit, pig, rat
• テクニック: immunohistochemistry: 1:100
• アイソタイプ: IgG
• UniProtアクセッション番号: P14136
• 輸送温度: wet ice
• 保管温度: 2-8°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... GFAP(2670)

詳細

詳細

Glial fibrillary acidic protein (GFAP) is a member of the class III intermediate filament protein family. It is heavily, and specifically, expressed in astrocytes and certain other astroglia in the central nervous system, in satellite cells in peripheral ganglia, and in non myelinating Schwann cells in peripheral nerves. In addition, neural stem cells frequently strongly express GFAP. Antibodies to GFAP are therefore very useful as markers of astrocytic cells. In addition, many types of brain tumors presumably derived from astrocytic cells, heavily express GFAP. GFAP is also found in the lens epithelium, Kupffer cells of the liver, in some cells in salivary tumors and has been reported in erythrocytes. GFAP is particular expressed in auricular chondrocytes.

免疫原

Synthetic peptide corresponding to C-terminus of human GFAP protein.

アプリケーション

Anti-GFAP antibody, Rabbit monoclonal has been used in immunocytochemistry and Immunohistochemistry.

生物化学的／生理学的作用

Glial fibrillary acidic protein (GFAP) maintains the structure and motility of astrocytes. Gfap mediates the interaction between neurons and glial cells. It is responsible for the integrity and function of blood-brain barrier. Myelination and brain injury induced astrogliosis is controlled by Gfap. Cytoskeleton disintegration is known to stimulate the release of Gfap. Upregulation of this gene is observed in traumatic brain injury such as intracerebral hemorrhage and thus serves as a biomarker. Mutation in the GFAP gene causes Alexander disease.

特徴および利点

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

物理的形状

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable