SAB4700515

Monoclonal Anti-CD71 antibody produced in mouse

clone MEM-75, purified immunoglobulin, buffered aqueous solution

• 別名: Anti-TFRC, Anti-Transferrin Receptor
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: mouse
• 結合体: unconjugated
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: MEM-75, monoclonal
• 形状: buffered aqueous solution
• 化学種の反応性: human
• 濃度: 1 mg/mL
• テクニック: flow cytometry: suitable
• アイソタイプ: IgG1
• NCBIアクセッション番号: NM_001128148.1
• UniProtアクセッション番号: P02786
• 輸送温度: wet ice
• 保管温度: 2-8°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... TFRC(7037)

詳細

詳細

Cluster of differentiation 71 (CD71), also known as transferrin receptor, is encoded by the gene mapped to human chromosome 3q29. CD71 is present on cells with high proliferation.

The antibody MEM-75 reacts with CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and T lymphocytes, macrophages and erythroid precursors; it is lost on resting blood leukocytes.

免疫原

NALM-6 human pre-B cell line

アプリケーション

Monoclonal Anti-CD71 antibody produced in mouse has been used in co-immunoprecipitation assay.

The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 4 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

生物化学的／生理学的作用

Cluster of differentiation 71 (CD71) functions as an iron regulatory protein. Overexpression of the gene has been associated with the development of various types of cancers, including cholangiocarcinoma (CCA). Thus, CD71 protein is considered as a potential therapeutic target for CCA and iron overload. The encoded protein facilitates mitochondrial respiration and reactive oxygen species (ROS) production in human pancreatic ductal adenocarcinoma (PDAC) cells, which is essential for their tumorigenic growth. Thus, aberrant expression of CD71 might also lead to the development of pancreatic cancer.

特徴および利点

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物理的形状

PBS（pH 7.4、15 mM アジ化ナトリウム含有）

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable