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由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
分子量
antigen 50 kDa
化学種の反応性
human, mouse, rat
濃度
~1 mg/mL
テクニック
ELISA: 1:20000
immunohistochemistry: 1:50-1:100
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... TNFRSF1A(7132)
詳細
Tumor necrosis factor receptor 1 (TNFR1) belongs to the TNFR superfamily and is ubiquitously expressed. It comprises an extracellular domain with a cysteine-rich motif, a transmembrane segment, and an intracellular domain with a “death domain” motif. The TNFR1 gene is mapped to human chromosome 12p13.31.
免疫原
The antiserum was produced against synthesized peptide derived from human TNF Receptor I.
Immunogen Range: 381-430
Immunogen Range: 381-430
アプリケーション
Anti-TNF Receptor I antibody produced in rabbit has been used in immunostaining at a dilution of 1:200.
生物化学的／生理学的作用
Tumor necrosis factor receptor 1 (TNFR1) is crucial for TNF for eliciting proinflammatory functions. Through its dead domain motif, TNFR1 interacts with the TNF receptor-associated death domain protein (TRADD). TNFR1 regulates cytotoxic signaling pathways. Blockage of TNFR1 in mouse model harboring respiratory syncytial virus (RSV) infection results in enhanced bronchoconstriction.
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
物理的形状
ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
最新バージョンのいずれかを選択してください：
Role of TNF-TNF Receptor 2 Signal in Regulatory T Cells and Its Therapeutic Implications.
Yang, et al.
Frontiers in Immunology, 9, 784-784 (2019)
The death domain of tumor necrosis factor receptor 1 is necessary but not sufficient for Golgi retention of the receptor and mediates receptor desensitization.
Gaeta, et al.
Laboratory Investigation; a Journal of Technical Methods and Pathology, 80, 1185-1194 (2019)
Dorothea R Morris et al.
Viruses, 12(10) (2020-10-22)
Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis in infants and young children. Although some clinical studies have speculated that tumor necrosis factor (TNF)-α is a major contributor of RSV-mediated airway disease, experimental evidence remains unclear or conflicting.
Antonio-Jesús Jiménez et al.
Neuropathology and applied neurobiology, 40(7), 911-932 (2014-04-09)
Here, we tested the hypothesis that glial responses via the production of cytokines such as transforming growth factor-beta 1 (TGFβ1) and tumour necrosis factor alpha (TNFα), which play important roles in neurodegenerative diseases, are correlated with the severity of congenital
Agnieszka Segiet et al.
Cytokine, 113, 185-194 (2018-12-13)
A growing body of evidence indicates that brain cytokines are involved in the control of the cardiovascular system. Tumour necrosis factor (TNF) is an archetypal cytokine, which exerts its proinflammatory actions via type 1 receptor (TNFR1). Interleukin 10 (IL-10) plays
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