おすすめの製品
由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
分子量
antigen 138 kDa
交差性
rat, mouse, human
濃度
~1 mg/mL
テクニック
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... KCNT1(57582)
詳細
Anti-KCNT1 antibody detects endogenous levels of total KCNT1 protein.
The KCNT1 (potassium sodium-activated channel subfamily T member 1) gene is mapped to human chromosome 9q34.3. It is widely expressed in the brain, heart and dorsal root ganglia and well distributed in the nervous system.
免疫原
The antiserum was produced against synthesized peptide derived from human KCNT1.
Immunogen Range: 1019-1068
Immunogen Range: 1019-1068
生物化学的/生理学的作用
Mutations in KCNT1 (potassium sodium-activated channel subfamily T member 1) is observed in different epileptic disorders including epileptic encephalopathy, nocturnal frontal lobe epilepsy and malignant migrating partial seizures in infancy. KCNT1 is associated with neural oscillation and general learning disability. It also controls pain sensation.
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
物理的形状
ウサギIgGのPBS溶液(Mg2+およびCa2+を含まず)、pH 7.4、150 mM NaCl、0.02% アジ化ナトリウム、50% グリセロール
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
最新バージョンのいずれかを選択してください:
Missense mutations in the sodium-gated potassium channel gene KCNT1 cause severe autosomal dominant nocturnal frontal lobe epilepsy.
Heron SE
Nature Genetics, 44(11), 1188-1190 (2012)
Mutations in KCNT1 cause a spectrum of focal epilepsies.
M?ller RS
Epilepsia, 56(9) (2015)
Epilepsy-Related Slack Channel Mutants Lead to Channel Over-Activity by Two Different Mechanisms.
Tang QY
Cell Reports, 9314(1), 129-139 (2016)
Stimulation of Slack K(+) Channels Alters Mass at the Plasma Membrane by Triggering Dissociation of a Phosphatase-Regulatory Complex.
Fleming MR
Cell Reports, 16(9), 2281-2288 (2016)
Characterization of two de novoKCNT1 mutations in children with malignant migrating partial seizures in infancy.
Rizzo F
Molecular and Cellular Neurosciences, 72, 54-63 (2016)
Global Trade Item Number
カタログ番号 | GTIN |
---|---|
SAB4502518-100UG | 4061837190049 |
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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