SAB4502022
Anti-NOTCH2 (Cleaved-Val1697) antibody produced in rabbit
affinity isolated antibody
別名:
Motch B, NOTC2, NOTCH2, NTC2, Neurogenic locus notch homolog protein 2 precursor
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About This Item
UNSPSCコード:
12352203
NACRES:
NA.41
結合体:
unconjugated
application:
ELISA
WB
WB
クローン:
polyclonal
化学種の反応性:
human, rat, mouse
citations:
7
テクニック:
ELISA: 1:10000
western blot: 1:500-1:1000
western blot: 1:500-1:1000
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由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
分子量
antigen 83 kDa
化学種の反応性
human, rat, mouse
濃度
~1 mg/mL
テクニック
ELISA: 1:10000
western blot: 1:500-1:1000
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
proteolytically cleaved (Val1697)
遺伝子情報
human ... NOTCH2(4853)
関連するカテゴリー
詳細
Anti-NOTCH2 (Cleaved-Val1697) antibody detects endogenous levels of fragment of activated NOTCH2 (Cleaved-Val1697) protein.
免疫原
The antiserum was produced against synthesized peptide derived from human NOTCH2.
Immunogen Range: 1678-1727
Immunogen Range: 1678-1727
生物化学的／生理学的作用
The NOTCH2 gene is known to be involved in the proliferation, cell cycle progression and colony formation of cancer cells. Upregulation of the gene is observed in hepatocellular carcinoma and salivary adenoid cystic carcinoma. Deletion of NOTCH2 increases the sensitivity of the cancer cells to chemotherapeutic agents such as 5-fluorouracil. NOTCH2 plays an important role in the regulation of liver development.
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
物理的形状
ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SAB4502022-100UG:
最新バージョンのいずれかを選択してください：
Giuseppina Catanzaro et al.
International journal of molecular sciences, 18(12) (2017-12-21)
The mechanisms by which microRNAs control pediatric high-grade gliomas (pHGGs) have yet to be fully elucidated. Our studies of patient-derived pHGG tissues and of the pHGG cell line KNS42 revealed down-regulation in these tumors of three microRNAs, specifically miR-107, miR-181c
Domenica Giannandrea et al.
Haematologica, 107(9), 2183-2194 (2022-03-11)
Multiple myeloma (MM) is an incurable hematologic neoplasm, whose poor prognosis is deeply affected by the propensity of tumor cells to localize in the bone marrow (BM) and induce the protumorigenic activity of normal BM cells, leading to events associated
Kai Dai et al.
Frontiers in immunology, 8, 320-320 (2017-04-07)
The mechanisms by which tumor-responsive CD8+ T cells are regulated are important for understanding the tumor immunity and for developing new therapeutic strategies. In current study, we identified the expression of 1810011o10 Rik, which is the homolog of human thyroid
Wen-Rui Wu et al.
Oncology reports, 36(1), 181-188 (2016-05-26)
The Notch pathway plays an important role in both stem cell biology and cancer. Notch2 was reported to be upregulated in human hepatocellular carcinoma (HCC) tissues. However, the biological function of Notch2 in human HCC cells has not yet been
Jing Qu et al.
Molecular and cellular biochemistry, 411(1-2), 135-141 (2015-10-03)
Many studies have explored whether the Notch signaling pathway has a tumor-suppressive or an oncogenic role in various tumors; however, the role of the Notch signaling pathway in salivary adenoid cystic carcinoma (SACC) is still unknown. In this study, we
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