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Key Documents

SAB4501318

Sigma-Aldrich

Anti-MGLUR2 antibody produced in rabbit

affinity isolated antibody

別名:

GPRC1C, GRM3, MGR3, Metabotropic glutamate receptor 3 precursor, glutamate receptor

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About This Item

UNSPSCコード:
12352203
NACRES:
NA.41

由来生物

rabbit

結合体

unconjugated

抗体製品の状態

affinity isolated antibody

抗体製品タイプ

primary antibodies

クローン

polyclonal

形状

buffered aqueous solution

分子量

antigen 95 kDa

化学種の反応性

rat, human, mouse

濃度

~1 mg/mL

テクニック

ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBIアクセッション番号

UniProtアクセッション番号

輸送温度

wet ice

保管温度

−20°C

ターゲットの翻訳後修飾

unmodified

遺伝子情報

human ... GRM2(2912)

詳細

Metabotropic glutamate receptor 2 (MGLUR2) with 872 amino acid residues is encoded by the gene mapped to human chromosome 3. MGLUR2 belongs to the class c of G-protein-coupled receptor (GPCRs) family. It is expressed mainly in the central nervous system (CNS) of rat brain and widely expressed in human adult and fetal brain. MGLUR2 is characterized with an α-helical helix 8 (H8) domain.

免疫原

The antiserum was produced against synthesized peptide derived from human mGluR2/3.

Immunogen Range: 823-872

生物化学的/生理学的作用

Metabotropic glutamate receptor (MGLUR2) is involved in the glutamatergic system in the brain. Overexpression of glutamate in brain areas such as the prefrontal cortex, hippocampus and amygdala leads to anxiety and schizophrenia, activation of MGLUR2 in these areas reduces the excitatory neurotransmission, therefore mGlu2 receptor might be considered as a potential target for the treatment of these diseases. MGLUR2 signaling inhibits adenylyl cyclase (AC) activity. MGLUR2 is crucial in the modulation of synaptic transmission.

特徴および利点

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

物理的形状

ウサギIgGのPBS溶液(Mg2+およびCa2+を含まず)、pH 7.4、150 mM NaCl、0.02% アジ化ナトリウム、50% グリセロール

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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保管分類コード

10 - Combustible liquids

WGK

nwg

引火点(°F)

Not applicable

引火点(℃)

Not applicable


試験成績書(COA)

製品のロット番号・バッチ番号を入力して、試験成績書(COA) を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

H Ohishi et al.
Neuroscience, 53(4), 1009-1018 (1993-04-01)
Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, which is coupled to the inhibitory cyclic AMP cascade, was investigated in the central nervous system of the adult rat by in situ hybridization. Transcripts of mGluR2 were specifically
Steve Davidson et al.
Pain, 157(9), 2081-2088 (2016-05-25)
We introduce a strategy for preclinical research wherein promising targets for analgesia are tested in rodent and subsequently validated in human sensory neurons. We evaluate group II metabotropic glutamate receptors, the activation of which is efficacious in rodent models of
Agostino Bruno et al.
PloS one, 7(8), e42023-e42023 (2012-08-08)
The recent elucidation of the X-ray structure of several class A GPCRs clearly indicates that the amphipathic helix 8 (H8) is a conserved structural domain in most crystallized GPCRs. Very little is known about the presence and the possible role
Driss El Moustaine et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(40), 16342-16347 (2012-09-19)
The eight metabotropic glutamate receptors (mGluRs) are key modulators of synaptic transmission and are considered promising targets for the treatment of various brain disorders. Whereas glutamate acts at a large extracellular domain, allosteric modulators have been identified that bind to
A Farinha et al.
British journal of pharmacology, 172(9), 2383-2396 (2015-01-13)
The activation of the metabotropic glutamate receptor 2 (mGlu2 ) reduces glutamatergic transmission in brain regions where excess excitatory signalling is implicated in disorders such as anxiety and schizophrenia. Positive allosteric modulators (PAMs) can provide a fine-tuned potentiation of these

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