SAB4500329

Anti-CCR7 antibody produced in rabbit

affinity isolated antibody

• 別名: C-C CKR-7, C-C chemokine receptor type 7, CC-CKR-7, CCR-7, MIP-3 β receptor
• MDL番号: MFCD03455130
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: antigen 42 kDa
• 化学種の反応性: human
• 濃度: ~1 mg/mL
• テクニック: ELISA: 1:40000; immunofluorescence: 1:100-1:500; western blot: 1:500-1:1000
• NCBIアクセッション番号: P32248
• UniProtアクセッション番号: P32248
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... CCR7(1236)

詳細

詳細

C-C motif chemokine receptor 7 (CCR7) also known as EBI1, is encoded by the gene mapped to human chromosome 17q12-q21.2. The encoded protein is a member of chemokine receptor family and is expressed mainly by B cells, T cells, and on activated mature dendritic cells (DCs).

CCR7 is a G protein-coupled seven-transmembrane domain receptor. It has two high-affinity ligands, secondary lymphoid chemokine (SLC) and EB11-ligand chemokine (ELC).

免疫原

The antiserum was produced against synthesized peptide derived from human CCR7.

Immunogen Range: 170-219

アプリケーション

Anti-CCR7 antibody produced in rabbit has been used for proximity ligation assay (PLA).

Anti-CCR7 antibody produced in rabbit has been used in immunofluorescence (1:50).

生物化学的／生理学的作用

C-C motif chemokine receptor 7 (CCR7) harmonizes the antigen-specific immune response by combining T cells, B cells, and dendritic cells (DCs), to form functional microenvironments in the secondary lymphoid organs. CCR7 controls trafficking of skin DC under both inflammatory and steady-state conditions. This protein is also involved in emigration pathway of mature DCs from the skin to regional lymph nodes in vivo. CCR7 oligomers function acts as a scaffolds to link distinct signaling pathways for cell migration. Interaction of CCR7 with its ligand, CCL21/6ckine is essential for preferential lymph node metastasis of gastric carcinoma.

CCR7 can stimulate the development of hepatocellular carcinoma (HCC). In human malignancies, CCR7 may act as an initiator of epithelial-mesenchymal transition (EMT).

特徴および利点

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物理的形状

ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable