SAB4500090

抗ADARB1抗体 ウサギ宿主抗体

affinity isolated antibody

• 別名: RNA-editing deaminase 1, RNA-editing enzyme 1, dsRNA adenosine deaminase
• MDL番号: MFCD02686608
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen 80 kDa
• 交差性: rat, mouse, human
• 濃度: ~1 mg/mL
• テクニック: ELISA: 1:20000; western blot: 1:500-1:1000
• NCBIアクセッション番号: P78563
• UniProtアクセッション番号: P78563
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... ADARB1(104)

詳細

詳細

Adenosine deaminase, RNA specific B1 (ADARB1) is encoded by the gene mapped to human chromosome 21q22.3, a region associated with familial bipolar disorder. ADARB1 is characterized with two double-stranded RNA-binding domains and a deaminase domain involved in editing action.

免疫原

The antiserum was produced against synthesized peptide derived from human ADARB1.

Immunogen Range: 481-530

生物化学的／生理学的作用

Adenosine deaminase, RNA specific B1 (ADARB1) enzyme plays a vital role in editing pre-mRNA of glutamate receptor B subunit. Combined effect of ADARB1 and HTR2C (5-Hydroxytryptamine Receptor 2C) variants contribute to the suicide attempt (SA) vulnerability in psychiatric patients. ADARB1 is a candidate gene for neurological diseases, such as bipolar affective disorder and epilepsy. Decrease in the activity of ADAR2 enzyme results in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor-mediated death of motor neurons in mice. ADARB1 enzyme is expressed consistently in carcinomas and sarcomas, and it is upregulated in lymphomas and seminomas when compared to normal tissues.

特徴および利点

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物理的形状

ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable