SAB4300342

Anti-BAD (Ab-136) antibody produced in rabbit

affinity isolated antibody

• 別名: Anti-BBC2 antibody produced in rabbit, Anti-BCL2-associated agonist of cell death antibody produced in rabbit, Anti-BCL2L8 antibody produced in rabbit
• MDL番号: MFCD02097156
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: ~23 kDa
• 化学種の反応性: rat, human, mouse
• 濃度: 1 mg/mL
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; western blot: 1:500-1:1000
• アイソタイプ: IgG
• 免疫原配列: (S-R-S-A-P)
• NCBIアクセッション番号: NP_004313.1
• UniProtアクセッション番号: Q92934
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... BAD(572)

詳細

詳細

BAD (BCL2 associated agonist of cell death) is a proapoptotic protein. It is a 184 kDa protein made of 168 amino acids. It belongs to the Bcl2 family of proteins. The gene encoding it is localized on human chromosome 11q13.

免疫原

Peptide sequence around aa. 134-138 (S-R-S-A-P), according to the protein BAD.

生物化学的／生理学的作用

Phosphorylated BAD (BCL2 associated agonist of cell death) has the ability to interact with 14-3-3 scaffold proteins in the cytoplasm. Dephosphorylated BAD is active and it moves to the outer membrane of mitochondria and make heterodimers with BCL-XL to prevent BCL-XL antiapoptotic activities.

特徴および利点

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ターゲットの説明

The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.

物理的形状

PBS（0.02％ アジ化ナトリウム、50％ グリセロール含有）

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable