SAB4300124

Anti-phospho-JAK2 (pTyr¹⁰⁰⁷) antibody produced in rabbit

affinity isolated antibody

• 別名: Anti-JTK10 antibody produced in rabbit, Anti-Janus kinase 2 (a protein tyrosine kinase) antibody produced in rabbit
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: ~125 kDa
• 化学種の反応性: mouse, rat, human
• 濃度: 1 mg/mL
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; western blot: 1:500-1:1000
• アイソタイプ: IgG
• 免疫原配列: (K-E-YP-Y-K)
• NCBIアクセッション番号: NP_004963.1
• UniProtアクセッション番号: O60674
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: phosphorylation (pTyr1007)
• 遺伝子情報: human ... JAK2(3717)

詳細

詳細

Janus kinase 2(JAK2) mapped on human chromosome 9p24, encodes a tyrosine kinase. The encoded protein is a member of the Jak family of protein. JAK2 is ubiquitously expressed. This protein contains a catalytic domain and protein–protein interaction domain.

免疫原

Peptide sequence around phosphorylation site of tyrosine 1007 (K-E-Y(p)-Y-K), according to the protein JAK2.

生物化学的／生理学的作用

Janus kinase 2(JAK2) plays an important role in the activities of cytokines receptors. Overexpression of JAK2 results in neuroblastoma. JAK2 mutations promote primary resistance to PD-1 (anti-programmed death protein 1) blockade therapy. In addition, mutations in the gene has also been observed in polycythaemia vera patients.

特徴および利点

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ターゲットの説明

Plays a role in leptin signaling and control of body weight.

物理的形状

PBS（0.02％ アジ化ナトリウム、50％ グリセロール含有）

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable