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詳細
ß-lactoglobulin also known as Bos d 5 allergen, can be detected in the mammary gland and highly expressive in the breasts. Bovine β-lactoglobulin (Beta-LG) is the major whey protein of cow′s milk1. This protein, which has 162 residues in its mature form, exists as a dimer in solution, where the dimer has a molecular weight of approximately 36 kDa 2. This protein is extensively a primary component that binds retinol 3. The ruminant animals have dimeric Beta-LG′s, which show very high sequence identity to bovine Beta-LG. Within a species, Beta-LG often exists in several genetic variants. The cow (Bos taurus), for example, has at least nine variants, labeled as A, B, C, D, E, H, I, J and W. The more common bovine Beta-LG variants (A, B, and C) respond differently to heat, a property of technological significance in the industrial processing of milk and for the characteristics of milk products 5. Bovine Beta-LG is stable at low pH, is resistant to proteolysis 6. Several variants have been identified, the main ones in the cow being labelled A and B 7 . Because of its abundance and ease of purification, it has been subjected to a wide range of biophysical studies.
特異性
β-Lactoglobulin from bovine milk were used as the immunogen.
アプリケーション
The antibody is recommended to be used in various immunological techniques, including immunoblot and ELISA. Monoclonal Anti-?-Lactoglobulin is immunospecific to β--Lactoglobulin as determined by an immunoblot assay. Detection of the β-Lactoglobulin band by immunoblotting is specifically inhibited by the immunogen.
生物化学的／生理学的作用
Beta-LG has a calyx fold, typical of the lipocalin protein superfamily, and shares with other lipocalins the ability to bind a variety of small hydrophobic molecules in vitro 4. b-Lactoglobulins are widely distributed. While some Beta-LG′s are monomeric, for example, horse, pig, and cat, most Beta-LG′s occur as dimers, especially, in the order of hoofed mammals.b-lactoglobulin is of direct interest to the food industry since its properties can variously be advantageous or disadvantageous in dairy products and processing. b -lactoglobulin is considered as a major milk allergen.
物理的形状
Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.
保管および安定性
For continuous use, store at 2-8°C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours. Protect from prolonged exposure to light.
免責事項
This product is for R&D use only, not for drug, household, or other uses. Please consult the Material Safety Data Sheet for information regarding hazards and safe handling practices.
保管分類コード
12 - Non Combustible Liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SAB4200881-100UL:
SAB4200881-BULK:
SAB4200881-25UL:
SAB4200881-VAR:
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