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由来生物
mouse
品質水準
抗体製品の状態
purified immunoglobulin
抗体製品タイプ
primary antibodies
クローン
2E12E6, monoclonal
フォーム
buffered aqueous solution
分子量
antigen 5 kDa
交差性
human
濃度
~1 mg/mL
テクニック
immunoblotting: 0.25-0.5 μg/mL using human recombinant peptide of MR-Pro ADM (amino acid 45-92).
indirect ELISA: 30-60 ng/mL using human recombinant peptide of MR-Pro ADM (amino acid 45-92) for coating.
アイソタイプ
IgG1
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... ADM (133)
詳細
Monoclonal Anti-MR-Pro ADM (mid-regional pro adrenomedullin) (mouse IgG1 isotype) is derived from the hybridoma 2E12E6 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with human recombinant protein. Mid-regional pro-adrenomedullin (MR-proADM) is obtained as a by-product of post-translational processing of prepro adrenomedullin (Adm, AM) peptide. This gene is located on human chromosome 11p15.
免疫原
human MR-Pro ADM recombinant protein.
アプリケーション
Anti-MR-pro ADM has been used in immunoblotting (~5 kDa) and indirect enzyme-linked immunosorbent assay (ELISA).
生物化学的／生理学的作用
Mid-regional pro-adrenomedullin (MR-proADM) has been suggested as a biomarker for plasma concentrations of adrenomedullin as it is stoichiometrically generated and relatively stable in the plasma. Upregulated levels of MR-pro ADM were associated with an increased risk of mortality and morbidity in patients with heart failure, independent of natriuretic peptides. It can stimulate vascular endothelial barrier function.
物理的形状
a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
最新バージョンのいずれかを選択してください：
Elevated levels of adrenomedullin in eutopic endometrium and plasma from women with endometriosis
Matson BC, et al.
Fertility and Sterility, 109(6), 1072-1078 (2018)
Mid-Regional Pro-Adrenomedullin (MR-proADM) as a Biomarker for Sepsis and Septic Shock: Narrative Review
Healthcare (Basel, Switzerland) , 6(3), 110-110 (2018)
Sex-specific effects of NLRP6/AVR and ADM loci on susceptibility to essential hypertension in a Sardinian population
Glorioso N, et al.
PLoS ONE, 8(10), e77562-e77562 (2013)
Adrenomedullin surges are linked to acute episodes of the systemic capillary leak syndrome (Clarkson disease)
Xie Z, et al.
Journal of Leukocyte Biology, 103(4), 749-759 (2018)
Mihael Potocki et al.
Current heart failure reports, 9(3), 244-251 (2012-06-27)
Circulating biomarkers have become increasingly important in diagnosing and risk-stratifying patients with heart failure (HF). While the natriuretic peptides have received much focus in the past decade, there is increasing interest in the role of other circulating biomarkers such as
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