おすすめの製品
由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
形状
buffered aqueous solution
化学種の反応性
human
濃度
~1 mg/mL
テクニック
immunohistochemistry: 5-10 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human pancreas sections
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... CHGA(1113)
詳細
CHGA (chromogranin A) is a granin family acidic glycoprotein. It resides in endocrine and neuroendocrine cells, where it is localized to secretory dense-core granules which store peptide hormones. It is a predominant protein of the chromaffin cell secretory granules.
免疫原
synthetic peptide corresponding to the GR-44 peptide in the C-terminal region of human Chromogranin-A , conjugated to KLH.
アプリケーション
Anti-Chromogranin A antibody produced in rabbit has been used in immunohistochemistry.
生物化学的／生理学的作用
CHGA (chromogranin A) is secreted in abnormal levels by neoplastic neuroendocrine cells, which might be linked with tumor growth and progression, as it might influence the different components of tumor stroma. It is a highly sensitive and specific biomarker for the diagnosis of NETs (neuroendocrine tumors). CHGA is processed to produce catestatin (CST), vasostatin-I, serpinin and pancreastatin (PST), which function as metabolic or cardiovascular-regulatory peptides. As this protein is co-stored and co-released with catecholamines, it plays an essential role in production of catecholamine storage vesicles. It functions as a circulating biomarker for gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) patients.
物理的形状
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
適切な製品が見つかりませんか。
製品選択ツール.をお試しください
保管分類コード
10 - Combustible liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SAB4200668-BULK:
SAB4200668-VAR:
IXO15483:
SAB4200668-100UL:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
A common genetic variant of the chromogranin A-derived peptide catestatin is associated with atherogenesis and hypertension in a Japanese population.
Choi Y et al
Endocrine Journal, 62(9), 797-804 (2015)
NANETS consensus guidelines for the diagnosis of neuroendocrine tumor.
Aaron I Vinik et al.
Pancreas, 39(6), 713-734 (2010-07-29)
A comparison of three chromogranin A assays in patients with neuroendocrine tumours.
Hoej LB et al
Journal of Gastrointestinal and Liver Diseases : JGLD, 23(4), 419-424 (2014)
Chromogranin A as a marker for diagnosis, treatment, and survival in patients with gastroenteropancreatic neuroendocrine neoplasm.
Wang YH et al
Medicine, 93(27), e247-e247 (2014)
Bruno Tota et al.
Frontiers in chemistry, 2, 64-64 (2014-09-02)
Together with Chromogranin B and Secretogranins, Chromogranin A (CGA) is stored in secretory (chromaffin) granules of the diffuse neuroendocrine system and released with noradrenalin and adrenalin. Co-stored within the granule together with neuropeptideY, cardiac natriuretic peptide hormones, several prohormones and
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）