おすすめの製品
由来生物
rabbit
品質水準
抗体製品の状態
IgG fraction of antiserum
抗体製品タイプ
primary antibodies
フォーム
buffered aqueous solution
分子量
~60 kDa
化学種の反応性
rat, human
テクニック
immunoblotting: 1:1,000-1:2,000 using rat kidney extracts (S1 fraction)
immunohistochemistry: 1:50-1:100 using formalin-fixed paraffin-embedded human duodenum
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... SLC40A1(30061)
rat ... Slc40a1(170840)
詳細
SLC40A1 (also known as ferroportin, FPN1), also called iron-regulated transporter 1 (IREG1), is an iron transporter expressed in liver, duodenum and kidney. SLC40A1 is also expressed in the brain, duodenal mucosa, in neuronal cells and endothelial cells of the blood-brain barrier.
免疫原
synthetic peptide corresponding to an internal sequence of human SLC40A1, conjugated to KLH.
アプリケーション
Anti-SLC40A1 antibody produced in rabbit has been used in western blotting and immunohistochemistry.
生物化学的／生理学的作用
Ferroportin 1(FPN1) plays a central role in systemic iron homeostasis and is critical for normal intestinal iron absorption. SLC40A1 is essential for development of the mouse embryo, forebrain patterning and neural tube closure. Hepcidin binds to and inhibits solute carrier family FPN1, thus preventing enterocytes of the intestines from secreting iron into the hepatic portal system, thereby functionally reducing iron absorption. Ferroportin in neuronal cells is required for cellular Fe2+ export, a process critical for normal neuronal function. It has been shown to interact with amyloid precursor protein (APP), to facilitate the iron export process from neuronal cells. Mutations in the FPN1 gene have been linked to hereditary hemochromatosis, a common disorder characterized by iron overload and multi-organ damage.
物理的形状
0.01 M PBS溶液(pH 7.4, 15 mMアジ化ナトリウム含有)。
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
IXO15438:
SAB4200575-VAR:
SAB4200575-BULK:
SAB4200575-200UL:
最新バージョンのいずれかを選択してください：
Differential regulation of estrogen in iron metabolism in astrocytes and neurons
Xu M, et al.
Journal of Cellular Physiology, 234(4), 4232-4242 (2019)
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
Donovan A, et al.
Cell Metabolism, 1(3), 191-200 (2005)
Jinzhe Mao et al.
Development (Cambridge, England), 137(18), 3079-3088 (2010-08-13)
Neural tube defects (NTDs) are some of the most common birth defects observed in humans. The incidence of NTDs can be reduced by peri-conceptional folic acid supplementation alone and reduced even further by supplementation with folic acid plus a multivitamin.
A T McKie et al.
Molecular cell, 5(2), 299-309 (2000-07-06)
Iron absorption by the duodenal mucosa is initiated by uptake of ferrous Fe(II) iron across the brush border membrane and culminates in transfer of the metal across the basolateral membrane to the portal vein circulation by an unknown mechanism. We
Natascha A Wolff et al.
Journal of cellular and molecular medicine, 15(2), 209-219 (2009-12-18)
Ferroportin 1 (FPN1) is an iron export protein expressed in liver and duodenum, as well as in reticuloendothelial macrophages. Previously, we have shown that divalent metal transporter 1 (DMT1) is expressed in late endosomes and lysosomes of the kidney proximal
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