SAB4200574

Anti-Claudin-4 (C-terminal) antibody produced in rabbit

affinity isolated antibody

• 別名: (CPER), CLDN4, CPE-R, CPETR1, Clostridium, Williams-Beuren syndrome chromosomal region 8(WBSCR8), enterotoxin, hCPE-R, perfringens, receptor
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 200
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• 化学種の反応性: rat, human, canine
• テクニック: immunoblotting: suitable; immunofluorescence: suitable; immunohistochemistry: suitable
• UniProtアクセッション番号: P01275
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... CLDN4(1364)

詳細

詳細

Claudin-4 is heterogeneously expressed in various tissues. It is enriched in endothelial cells (ECs), including the blood-brain barrier, and is also expressed in gut and kidney. It is mapped to human chromosome 7q11.23. Claudin-4 is associated with the tight junction strands in kidney epithelial cells.

特異性

Anti-Claudin-4 (C-terminal) specifically recognizes human, rat and dog claudin-4.

アプリケーション

Anti-Claudin-4 (C-terminal) antibody produced in rabbit has been used in:

• immunoblotting
• immunofluorescence
• immunohistochemistry

生物化学的／生理学的作用

Claudin-4 is involved in maintaining cellular polarity. It favors sodium chloride absorption and acts as a cation-barrier. Claudin-4 expression has been shown to be deregulated in several cancers, with aberrant expression in ovarian, breast, prostate and pancreatic carcinomas. The gene location of claudin-4 is a Williams-Beuren syndrome critical region.

物理的形状

Supplied as a solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

保管および安定性

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable