SAB4200539

Anti-Myocardin antibody produced in rabbit

affinity isolated antibody

• 別名: Anti-MYCD, Anti-MYOCD
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen ~107 kDa
• 化学種の反応性: rat, human, mouse
• 強化検証: recombinant expression; Learn more about Antibody Enhanced Validation
• テクニック: immunohistochemistry: 5-10 μg/mL using human and chicken heart.; indirect immunofluorescence: 2-4 μg/mL using A10 cells.; western blot: 1.5-3.0 μg/mL using extracts of Hct116 cells
• UniProtアクセッション番号: Q8IZQ8
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... MYOCD(93649) ; mouse ... Myocd(214384) ; rat ... Myocd(246297)

詳細

詳細

Anti-Myocardin specifically recognizes human, rat and chicken myocardin (MYOCD). Myocardin is encoded by the gene mapped to human chromosome 17p11.2. It contains a conserved SAP (SAF-A/B, Acinus, and PIAS) domain, involved in the regulation of nuclear organization, chromosomal dynamics and apoptosis. The encoded protein is expressed in a precise developmentally regulated, lineage-restricted pattern in the embryo and during postnatal development.

免疫原

a synthetic peptide corresponding to an internal sequence of human myocardin, conjugated to KLH. The corresponding sequence is identical in human myocardin isoform 2 and in rat and mouse myocardin.

生物化学的／生理学的作用

Myocardin (MYOCD) acts as an important smooth and cardiac muscle-specific transcriptional coactivator of serum response factor (SRF). It also plays an essential role in smooth muscle cell (SMC) differentiation. The encoded protein regulates bone morphogenetic protein 10 (BMP10) expression and is required for cardiac development, as well as cardiomyocyte survival and maintenance of heart function. MYOCD expression is associated with the development of atherosclerosis, Alzheimer′s disease and malignant transformation.

物理的形状

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable