SAB4200226

Anti-PGC-1α(N-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• 別名: 抗LEM6抗体
• MDL番号: MFCD03097133
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen ~120 kDa
• 化学種の反応性: human
• 強化検証: recombinant expression; recombinant expression; Learn more about Antibody Enhanced Validation
• 濃度: ~1.0 mg/mL
• テクニック: western blot: 1-2 μg/mL using HEK293-T cells expressing human PGC-1α
• UniProtアクセッション番号: Q9UBK2
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... PPARGC1A(10891)

詳細

詳細

PPARG coactivator 1 α (PPARGC1A), a master transcriptional coactivator is a 91kDa multifunctional regulatory factor, encoded by the gene mapped to human chromosome 4p15.1. The encoded protein is mainly expressed in heart, skeletal muscle and kidney.

アプリケーション

Anti-PGC-1α(N-terminal) antibody produced in rabbit has been used in immunoblotting.

生物化学的／生理学的作用

PPARG coactivator 1 α (PPARGC1α) integrates and regulates several metabolic pathways in response to external stimuli. PGC-1α regulates adaptive thermogenesis in brown adipose tissue and insulin signaling in skeletal muscle by activation of central metabolic and energy-related genes. It has a central role in the regulation of liver gluconeogenesis, β-oxidation of fatty acids and ketogenesis, by coactivation of key enzymes in the metabolic pathway, indicating that PGC-1α plays an important role as a global regulator of liver metabolism during fasting. PGC-1a is also a potent activator of mitochondrial biogenesis by coactivation of estrogen related receptor α(ERRα), nuclear respiratory factors (NRF)-1 and NRF-2. PGC-1a has been shown to suppress the generation of reactive oxygen species (ROS) and neurodegeneration by protecting neuronal cells from oxidative stress-mediated death. PGC-1α has been recently proposed to control muscle plasticity, to suppress broad inflammatory response and mediate the beneficial aspects of exercise.

物理的形状

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable