SAB4200201

Anti-Cyclophilin B antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• 別名: 抗CYP-S1抗体, 抗CYPB抗体, 抗PPIB抗体
• MDL番号: MFCD02265740
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: ~20 kDa
• 化学種の反応性: human, rat, monkey, mouse
• 強化検証: independent; Learn more about Antibody Enhanced Validation
• 濃度: ~1.0 mg/mL
• テクニック: indirect immunofluorescence: 5-10 μg/mL using mouse 3T3 cells; western blot: 0.5-1.0 μg/mL using whole extracts of human HepG2 and rat NRK cells
• UniProtアクセッション番号: P23284
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... PPIB(5479) ; mouse ... Ppib(19035)

詳細

詳細

Anti-Cyclophilin B is produced in rabbit using as the immunogen a synthetic peptide corresponding to a fragment of human Cyclophilin B conjugated to KLH. Cyclophilin B (CypB) is a 21 kDa protein encoded by the PPIB gene, that belongs to the cyclophilin family, a highly conserved class of proteins originally identified as cellular binding proteins for the immunosuppressive drug cyclosporin A. CypB is mainly located within the endoplasmic reticulum (ER) of all cell types. CypB is involved in inflammation, viral infection and cancer.

アプリケーション

Anti-Cyclophilin B antibody produced in rabbit has been used:

• immunoblotting
• immunofluorescence
• in immunocapture-polymerase chain reaction (PCR) to study the interactions between CypB and Tomato yellow leaf curl virus (TYLCV) coat protein (CP).

生物化学的／生理学的作用

Cyclophilins are peptidyl-prolyl cistrans isomerases (PPIases) that assist protein folding by catalysing the isomerization of peptidyl-proline bonds. Cyclophilin B (CypB) also plays an important role in protecting cells against ER stress via its PPIase activity. Mutations in the PPIB gene give rise to recessive forms of osteogenesis imperfecta and knockdown of this gene decreases cell growth, proliferation and migration.

物理的形状

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable