おすすめの製品
由来生物
rabbit
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
分子量
antigen ~55 kDa
包装
antibody small pack of 25 μL
濃度
~1.5 mg/mL
テクニック
indirect immunofluorescence: 5-10 μg/mL using NIH3T3 cells
western blot: 1.5-3.0 μg/mL using A431 cell extract
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... CORO1C(23603)
mouse ... Coro1c(23790)
rat ... Coro1c(501841)
詳細
Coronin-1C (also known as CORO1C, Coronin-3, HCRNN4) belongs to the coronin family of tryptophan-aspartic acid (WD) 40 repeat-containing proteins. Coronin-1C is ubiquitously expressed and co-localizes with F-actin. In fibroblasts, CORO1C is localized both in the cytosol and in the submembrane cytoskeleton, especially at lamellipodia and membrane ruffles.
アプリケーション
Anti-Coronin-1C (C-terminal) antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
生物化学的／生理学的作用
Coronins appear to function primarily in association with the membrane cytoskeleton through interaction with F-actin and the actin-related protein (Arp2/3) complex. They localize to submembrane areas and regulate cell motility and cytoskeletal rearrangement. important in cytokinesis, cell motility, endocytosis, axonal growth, wound healing and signal transduction by altering actin dynamics. Coronin-1C is abundantly expressed in the central nervous system (CNS) during embryogenesis and first postnatal stages and in primary oligodendrocytes.
物理的形状
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SAB4200117-BULK:
SAB4200117-200UL:
SAB4200117-VAR:
SAB4200117-25UL:
最新バージョンのいずれかを選択してください：
Oligomerization, F-actin interaction, and membrane association of the ubiquitous mammalian coronin 3 are mediated by its carboxyl terminus
Spoerl Z, et al.
The Journal of Biological Chemistry, 277(50), 48858-48867 (2002)
Coronin proteins as multifunctional regulators of the cytoskeleton and membrane trafficking
Rybakin V and Clemen CS
Bioessays, 27(6), 625-632 (2005)
Coronin 3 involvement in F-actin-dependent processes at the cell cortex
Rosentreter A, et al.
Experimental Cell Research, 313(5), 878-895 (2007)
Isolation and chromosomal assignment of a novel human gene, CORO1C, homologous to coronin-like actin-binding proteins
Iizaka M, et al.
Cytogenetic and genome research, 88(3-4), 221-224 (2000)
Coronin 3 and its role in murine brain morphogenesis
Hasse A, et al.
The European Journal of Neuroscience, 21(5), 1155-1168 (2005)
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