SAB4200073

Anti-Transglutaminase-2 (C-terminal) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody

• 別名: 抗TG2抗体, 抗TGC抗体, 抗TGM2抗体
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen ~78 kDa
• 交差性: human
• 包装: antibody small pack of 25 μL
• 濃度: ~1.5 mg/mL
• テクニック: immunohistochemistry: 5-10 μg/mL using formalin-fixed and paraffin embedded human placenta; immunoprecipitation (IP): 15-30 μg using human placenta extracts; indirect immunofluorescence: 2-4 μg/mL using U87 cells; western blot: 1-2 μg/mL using U87 cell extracts
• UniProtアクセッション番号: Q07283
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... TGM2(7052)

詳細

詳細

Tranglutaminase-2 (also known as TGM2, TG2), is a widely expressed, multifunctional protein.

アプリケーション

Anti-Transglutaminase-2 (C-terminal) antibody produced in rabbit has been used in:

• immunoblotting
• immunoprecipitation
• immunofluorescence
• immunohistochemistry

生物化学的／生理学的作用

Tranglutaminase-2 possesses enzymatic and GTPase activities, involved in multiple cell functions, including cell adhesion and cell signaling. TGM2 functions as a Ca²⁺-dependent enzyme capable of crosslinking both cytosolic and extracellular matrix proteins by catalyzing the formation of isopeptide bonds between lysine and glutamine residues. TGM2 is involved in the regulation of cell-matrix adhesion, cytoskeletal structure, cell migration and apoptosis. It is activated in response to tissue injury and plays an important role in wound healing and immune response. TGM2 is a major autoantigen in celiac disease and altered TGM2 expression or activity may be associated with Alzheimer′s disease, arteriosclerosis, type-2 diabetes and cancer metastasis in numerous forms of cancer.

物理的形状

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable