SAB4200024

モノクロナール抗Notch 1 ラット宿主抗体

clone ICN 5B5, purified from hybridoma cell culture

• 別名: 抗TAN1,hN1,神経性遺伝子座ノッチホモログタンパク質1抗体, 抗転座関連ノッチタンパク質抗体, 抗転座関連ノッチホモログ1(ショウジョウバエ)抗体
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rat
• 結合体: unconjugated
• 抗体製品の状態: purified from hybridoma cell culture
• 抗体製品タイプ: primary antibodies
• クローン: ICN 5B5, monoclonal
• 形状: buffered aqueous solution
• 分子量: antigen ~120 kDa
• 化学種の反応性: human
• 包装: antibody small pack of 25 μL
• 濃度: ~1.0 mg/mL
• テクニック: western blot: 2-4 μg/mL using whole extract of human Jurkat cells and developing with a sensitive film
• アイソタイプ: IgG2b
• UniProtアクセッション番号: P46531
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... NOTCH1(4851)

詳細

詳細

Monoclonal Anti-Notch 1 (rat IgG2b isotype) is derived from the hybridoma ICN 5B5 produced by the fusion of mouse myeloma cells and splenocytes from rat immunized with a recombinant fusion protein corresponding to a fragment of human Notch 1 fusion protein. Notch receptor 1 (Notch1) gene is located on human chromosome 9q34.

アプリケーション

Monoclonal Anti-Notch 1 antibody produced in rat has been used in immunoblotting.

生物化学的／生理学的作用

In chronic obstructive pulmonary disease, notch receptor 1 (Notch1) helps to modulate endothelial apoptosis via the extracellular signal-regulated kinase (ERK) pathway. Overexpression of Notch1 helps to guard endothelial cell from apoptosis. Knockdown of Notch1 results in the enhancement of apoptotic cells. Notch1 serves as a tumor suppressor gene in mammalian epidermis and is a determinant of keratinocyte differentiation. Notch signaling is believed to participate in several human neoplasms including T-cell acute lymphoblastic leukemia.

物理的形状

0.01 M PBS溶液(pH 7.4, 15 mMアジ化ナトリウム含有)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable