SAB3700041

Anti-Bovine IgM (μ-chain specific) antibody produced in rabbit

whole antiserum, lyophilized powder

• UNSPSCコード: 12352203
• NACRES: NA.46

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: whole antiserum
• 抗体製品タイプ: secondary antibodies
• クローン: polyclonal
• 形状: lyophilized powder
• 化学種の反応性: bovine
• テクニック: immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• 輸送温度: wet ice
• 保管温度: 2-8°C
• ターゲットの翻訳後修飾: unmodified

詳細

詳細

During the B-cell development, IgM (immunoglobulin M) is the first expressed antibody. It is present as a monomer on the surface of naive B cells. Antigenic stimulation and upon maturation, the monomeric IgM units (190kDa), are linked by disulfide bonds to form a pentameric immunoglobulin structure. It also but rarely forms a hexameric structure. The pentameric IgM is linked by a disulfide bond, a polypeptide chain and a J-chain. The μ -chain consists of five domains- VH, Cμ1, Cμ2, Cμ3 and Cμ4.

特異性

This product was prepared from monospecific antiserum by a delipidation and defibrination. Assay by immunoelectrophoresis resulted in a single precipitin arc against Bovine IgM and Bovine Serum. No reaction was observed against Bovine IgG F(ab′)2 or Bovine IgG F(c).

免疫原

Bovine IgM mu heavy chain

生物化学的／生理学的作用

The J-chain of the multimeric IgM (immunoglobulin M) structure is responsible for secretion at the mucosal surfaces. The pentameric form of IgM, has a greater affinity towards antigens (with multiple repeating epitopes) compared to the monomers. IgM pentamer enables better opsonization of antigens for destruction and fixing complement.

物性

Antibody format: Antiserum

物理的形状

0.02 M リン酸カリウム、0.15 M 塩化ナトリウム、pH 7.2

再構成

Reconstitute with 1.0 mL deionized water (or equivalent).

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable